8-P005 Rhabdomere twisting of Drosophila photoreceptors is influenced by MAP kinases ERK and JNK
نویسندگان
چکیده
منابع مشابه
8-P005 Rhabdomere twisting of Drosophila photoreceptors is influenced by MAP kinases ERK and JNK
manipulating spindle by laser, we showed that the spindle asymmetry is essential for asymmetric nuclear localization of b-catenin. Because a kinesin inhibitor disrupted asymmetry of b-catenin localization, we propose that kinesin dependent transport of b-catenin along astral microtubules causes the enhancement of nuclear b-catenin export. This process occurs more efficiently in the anterior sid...
متن کاملRhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels
Phosphatidic acid (PA) is postulated to have both structural and signaling functions during membrane dynamics in animal cells. In this study, we show that before a critical time period during rhabdomere biogenesis in Drosophila melanogaster photoreceptors, elevated levels of PA disrupt membrane transport to the apical domain. Lipidomic analysis shows that this effect is associated with an incre...
متن کاملSignal Transduction by the JNK Group of MAP Kinases
et al., 1994). JNK is activated by treatment of cells with cytokines (e.g., TNF and IL-1) and by exposure of cells to many forms of environmental stress The purpose of this review is to summarize recent advances that have been made toward understanding the JNK signaling pathway. It is now known that JNK Cells respond to changes in the physical and chemical is required for embryonic morphogenesi...
متن کاملSuperoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.
BACKGROUND/AIMS In liver diseases, reactive oxygen species (ROS) are involved in cell death and liver injury, but the mechanisms are not completely elucidated. To elucidate the mechanisms of hepatocyte cell death induced by the ROS superoxide anions and hydrogen peroxide, primary cultures of hepatocytes were exposed to the superoxide anion donor menadione (10-50 micromol/L) or H2O2 (1-5 mmol/L)...
متن کاملPhosphorylation of caldesmon by ERK MAP kinases in smooth muscle.
Phosphorylation of h-caldesmon has been proposed to regulate airway smooth muscle contraction. Both extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein (MAP) kinases phosphorylate h-caldesmon in vitro. To determine whether both enzymes phosphorylate caldesmon in vivo, phosphorylation-site-selective antibodies were used to assay phosphorylation of MAP kinase consensus s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.312